Pirfenidone High Purity Pharmaceutical Raw Material CAS 53179-13-8 CAS NO.53179-13-8

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Min.Order: 10 Gram
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Product Details

Keywords

53179-13-8
53179-13-8
53179-13-8

Quick Details

ProName: Pirfenidone High Purity Pharmaceutical...
CasNo: 53179-13-8
Molecular Formula: C12H11NO
Appearance: white crystalline powder
Application: use in chemical
DeliveryTime: within a week
PackAge: bags
Port: Shanghai
ProductionCapacity: 12 Kilogram/Day
Purity: 99%
Storage: Kept in a well-closed, light-resistant...
Transportation: by sea or express
LimitNum: 10 Gram
Moisture Content: 0.001
Impurity: 0.001
Water content: 0%

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Our products have exported to Germany, Spain, UK, USA, Australia, Middle East, and so on other countries, and we have got very good feedback from our customers.so you can trust us.
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Details

Pirfenidone High Purity Pharmaceutical Raw Material CAS 53179-13-8

Product Description:

Pirfenidone
CAS: 53179-13-8
MF: C12H11NO
FW:185.22
Other Name: 5-Methyl-N-phenyl-2-1H-pyridone
Appearance: White crystal powder
Melting point: 102--109
Solubility: DMSO: 10 mg/mL, soluble
Loss on drying <1.0%
Known single impurity <1.0%
Unknown single impurity <0.5%
Total impurity <2.0%
Assay(as dried) 99%min

Payment:T/T, and Money Gram
Delivery:Within 24hours After Your Payment
Express: EMS, DHL, FedEx, etc(door-to-door)

Application:

In vitro, pirfenidone can inhibit the uterine flesh tumour cells and leiomyoma cells proliferation. Pirfenidone can inhibit the TGF - beta - 1 inducing fibroblast collagen formation. Inhibition of PDGF, FGF and TGF - beta - 1 inducing fibroblast proliferation. In hamster model, pirfenidone, taken by mouth, that can the prevention and treatment of pulmonary fibrosis induced by bleomycin. Pirfenidone can prevent the sclerosing peritonitis in rats induced by chemical, can also be keloid grafting for the treatment of nude mice. Pirfenidone 0.01 1 mg/ml can suppress the matrix and dose dependent manner serum stimulate uterine fibroids and leiomyoma cell DNA synthesis, the compound has no cytotoxic effect, has no effect on collagen mRNA level also. Pirfenidone in hamster pulmonary fibrosis model can reduce the disease before the collagen I mRNA level enhancement, reduce the level of the lung hydroxyproline and malondialadehyde and lung preserved ammonia acyl hydroxylase activity.

COA:

Item	Standard
Appearance	White crystal powder
Melting Point	102--109C
Loss on drying	<1.0%
Known single impurity	<1.0%
Unknown single impurity	<0.5%
Total impurity	<2.0%
Assay(as dried)	99%