China (Mainland)
Factory Price 99% Topiramate Manufacturer CAS 97240-79-4 For Antiepileptic CAS NO.97240-79-4
- FOB Price: USD: 1.00-2.00 /Metric Ton Get Latest Price
- Min.Order: 10 Gram
- Payment Terms: L/C
- Available Specifications:
EP/BP/USP(1-10)Metric TonEP/BP/USP(11-100)Metric Ton
- Product Details
Keywords
- 97240-79-4
- 97240-79-4
- 97240-79-4
Quick Details
- ProName: Factory Price 99% Topiramate Manufactu...
- CasNo: 97240-79-4
- Molecular Formula: C12H21NO8S
- Appearance: white crystalline powder
- Application: use in chemical
- DeliveryTime: within a week
- PackAge: bags
- Port: Shanghai
- ProductionCapacity: 12 Kilogram/Day
- Purity: 99%
- Storage: Kept in a well-closed, light-resistant...
- Transportation: by sea or express
- LimitNum: 10 Gram
- Moisture Content: 0.001
- Impurity: 0.001
- Water content: 0%
Superiority
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1,Best Quality: Our products have exported to Germany, Spain, UK, USA, Australia, Middle East, and so on other countries, and we have got very good feedback from our customers.so you can trust us. 2, Payment method: for example T/T, Westerm Union,other 3, Excellent Service: Best service and after-sales service to all clients. 1)We will ship the goods within 5days after get your payments.If you want to cancel or change order, please tell me within 24hours after you finish the payment.. 2)We will ship the goods that you order from us by DHL, UPS, TNT and EUB.We will decided to choose which courier depend on different countries.To find the best way to delivery the goods for you. 3)As usual you can get the goods with in 4-7days.If the goods were lost or not received for other reasons, please contact us immediately. 4,Fast and safe delivery: Sample Order : As usual you can get the goods within 4-7days. We can send it via HKems, HK Air Post, DHL or other methods. We have a professional and stable logistics, and we can deliver the package smoothly around 3 to 5 days. Bulk Order: Shipped via sea or air, it's according to your requirement, delivery time is 7-15days after payment. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our customers and principals. With our high-performance teamwork centers and associated production sites for custom synthesis, we ensure effective professional response and offer extensive applications-related consulting and compliance regulation services. |
Details
Factory Price 99% Topiramate Manufacturer CAS 97240-79-4 For Antiepileptic
Details :
| Product name | Topiramate |
| CAS NO | 97240-79-4 |
| MF | C12H21NO8S |
| MW | 339.36 |
| EINECS | 200-659-6 |
| Appearance | White Powder |
| Usage |
1. anticonvulsant, antimigraine, GABA-A agonist, AMP/kinate glutamate receptor antagonist, carbonic anhydrase inhibitor. 2. Used for the treatment and control of partial seizures and severe tonic-clonic (grand mal) seizures and also for the prevention of migraine headaches. In children it is also used for treatment of Lennox-Gastaut syndrome. |
Topiramate Description:
Topiramate (the TPM) is a naturally existing monosaccharide D-fructose sulfide, and together with felbamate, lamotrigine and vigabatrin are current several broad-spectrum anti-epileptic drugs with relatively wide clinical application and can be used to control different types of epilepsy with excellent efficacy and pharmacokinetics.
This product is generally used for the adjuvant treatment of antiepileptic drugs and is effective in treating simple and complex seizures as well as systemic tonic-clonic seizures and can also be used for the treatment of infantile spasms. Features of this product include excellent long-term efficacy, no significant resistance as well as being able to be used alone for antiepileptic purpose.
But in cases of being applied to children or fast increase of the amount can cause cognitive impairment and neurotoxicity, and easy to trigger kidney stones.
Topiramate Ptoduct Application:
In 1980, scientists had first successfully synthesized topiramate in the laboratory. It had been applied to patients with epilepsy for the first time in 1986. In 1995, it was approved for entering into the market of UK for the first time. Its basic structure is fructopyranose sulfamate. Unlike other kinds of anti-epileptic drug, TPM has various kinds of anti-epileptic mechanisms including blocking the voltage-dependent sodium channels, enhancing the activity of GABA in the location of the γ- aminobutyric acid A (GABAA) receptor as well as blocking the activity of the AMPA glutamate receptor. In addition, there is still mild effect of carbonic anhydrase inhibitors.
Europe and the United States had conducted double-blind, placebo-controlled studies and demonstrated that the adjunctive therapy with topiramate has excellent efficacy, safety and is well tolerated in the treatment of various types of refractory epilepsy. Now it has begun with topiramate monotherapy and has also achieved good results with 62% of patients with epileptic seizures disappearing completely.
COA:
| Items |
Specifications |
Results |
| Appearance | White to off-white powder, Freely soluble in dichloromethane | White powder, Freely soluble in dichloromethane |
| Identification | Infared Absorption | Complies |
| The retention time of the major peak in the chromatogram of the Assay prepration corresponds to that in the chromatogram of the standard preparation, as obtained in the assay | complies | |
| Specific rotation | Between -28.6°and -35.0°, measured at 20° | -32.8° |
| Water | not more than 0.5% | 0.12% |
| residue on ignition | not more than 0.2% | 0.11% |
| Heavy metals | not more than 0.001% | complies |
| related compounds by HPLC(Test1) | Fructose not more than 0.3% Compound A not more than 0.3% Other individual impurity not more than 0.1% Total impurities not more than 0.5% |
Fructose: 0.03% Compound A:0.04%individual impurity Total impurities: 0.07% |
| Particle size | 90% less than 350 microns | complies |
| Limit of sulfamate and sulfate | Sulfamate ion not more than 0.10% Sulfate ion not more than 0.10% | complies |
| Residual Solvent | Methylene Chloride not more than 250μg/g | not detected |
| Acetone not mor than 2500μg/g | ||
| Isopropanol not more than 5000μg/g | ||
| Ethanenitrile not more than 400μg/g | ||
| n-hexane not more than 290μg/g | ||
| Ethyl Acetate not more than 2500μg/g | ||
| Pyridine not more than 100μg/g | ||
| Assay | Topiramate contains not less than 98.0% and not more than the equivalent of 102.0% of C12H21NO8S, calculated with reference to the Anhydrous Basis | 99.80% |
| Conclustion | The material complies with respect to USP35 | |