China (Mainland)
High purity Decitabine with best quality CAS NO.2353-33-5
- Min.Order: 10 Gram
- Payment Terms: L/C,T/T,Other
- Product Details
Keywords
- 5-Aza-2'-deoxycytidine
- purity 99% Decitabine
- high quality cas 2353-33-5
Quick Details
- ProName: High purity Decitabine with best quali...
- CasNo: 2353-33-5
- Molecular Formula: C8H12N4O4
- Appearance: white crystalline powder
- Application: API
- DeliveryTime: within in 5-7 working days after recei...
- PackAge: 25kg/paper drum or as customers' requi...
- Port: Wuhan, Shanghai, Guangzhou, Tianjin po...
- ProductionCapacity: 200 Kilogram/Week
- Purity: 98%-102.0%
- Storage: stored at dry, cool and avoid light
- Transportation: by sea/by express
- LimitNum: 10 Gram
Superiority
1, High quality with competitive price:
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1) Professional service and rich experience make customers feel at ease, adequate stock and fast delivery meet your desire.
2) Market feedback and goods feedback are appreciated, meeting customers's requirement is our responsibility.
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Details
Basic information
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Product Name: |
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Synonyms: |
4-amino-1-(2-deoxy-beta-d-erythro-pentofuranosyl)-s-triazin-2(1h)-on;4-amino-1-(2-deoxy-beta-d-erythro-pentofuranosyl)-s-triazin-2(1h)-one;5-azadeoxycytidine;5-triazin-2(1h)-one,4-amino-1-(2-deoxy-beta-d-erythro-pentofuranosyl)-3;2'-DEOXY-5-AZACYTIDINE;4-AMINO-1-(2-DEOXY-BETA-D-RIBOFURANOSYL)-1,3,5-TRIAZIN-2(1H)-ONE;5-AZA-2'-DEOXYCYTIDINE;5-AZA-CDR |
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CAS: |
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MF: |
C8H12N4O4 |
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MW: |
228.21 |
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Product Categories: |
API;Bases & Related Reagents;Nucleotides;analog of cytosine;Intermediates & Fine Chemicals;Pharmaceuticals;Epigenetics;Inhibitor;Deoxycytidine;Anti-cancer&immunity;Inhibitors |
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Mol File: |
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Chemical Properties |
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melting point |
~200 °C (dec.) |
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boiling point |
485.8 °C at 760 mmHg |
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density |
1.9 g/cm3 |
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flashing point |
247.6 °C |
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vapor pressure |
1.78E-11 mmHg at 25 °C |
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storage temp. |
−20°C |
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solubility |
acetic acid/water (1:1): 50 mg/mL, easily absorb moisture,hardly soluble in water,slightly dissolving in methanol,soluble in dimethyl sulfoxide,practically soluble in acetone and methylene chloride |
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stability |
Stable. May be light or air sensitive. Incompatible with strong oxidizing agents. |
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Usage And Synthesis |
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Chemical Properties |
white crystalline powder |
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Usage |
Used as cancer treatment, in particular to inhibit the growth of pancreatic endocrine tumor cell lines. |
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Decitabine is a potent inhibitor of DNA methylation with IC50 of 438 nM and 4.38 nM in HL-60 and KG1a cells, respectively |
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General Description |
Used as a drug. |
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Air & Water Reactions |
Probably light and air sensitive. Water soluble. Decomposes in aqueous solution at a rate that depends on pH: at pH 7 the drug is more stable than at pH 9, but is less stable than at pH 6. At pH 7 and 99°F, approximately 7% conversion occurs in 1 hour . |
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Fire Hazard |
Flash point data for 5-Aza-2'-deoxycytidine are not available. 5-Aza-2'-deoxycytidine is probably combustible. |
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Biological Activity |
Cytosine analog that once incorporated into DNA acts as a suicide substrate for DNA methyltransferase. Inhibits DNA methyltransferase and results in DNA hypomethylation and activation of silent genes. Chemotherapeutic agent; suppresses growth of human tumor cell lines. Demethylates differentiation-related genes; reverses embryonic stem cell differentiation. |
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