High Quality Ethynyl Estradiol for Female Health Care CAS 57-63-6 CAS NO.57-63-6

1. Hubei Jusheng Technology Co., Ltd.,  is a global chemical industry manufacturers and suppliers of pharmaceuticals and intermediates in China.

2. The yearly production capacity is 50000MT, 80% for export.We have a professinal export team. Both by Air and by Sea,we ensure that we meet the customer expectations with promptness.
3. Our company facing global High-tech pharmaceutical raw materials, high complex new type intermediates, fine chemicals custom synthesis, scale-up production and Rare chemicals trade. Corey have well-equipped machine, strong technical force and considerate marketing team service.
4. We also have rich experience advantage in basic research, small scale process development, scale-up, industrial technology development & production and cost control.  

Ethinyl estradiol
Alias:Aceto-sterandryl;Amenoron;Chee-O-Gen;Esteed;Estoral;Estorals;Estradiol, 17-ethynyl-;Ethidol;Ethinoral;Ethynylestradiol;Ethynyloestradiol;Eticyclin;Eticyclol;Follicoral;Ginestrene;Linoral;Lynoral
Purity :99%
CAS Registry Number:57-63-6
Einecs No:200-342-2
Grade :Pharmaceutical Grade
Storage:Shading, confined preservation
Manufacturer :Sai Chuang
Delivery time :Within 12 hours upon receipt of payment
Delivery:EMS, DHL, TNT, FedEx, UPS
Usage :Estrogen, plus progestogen as oral contraceptive

2.Product description:

MF:C20H24O2
MW:296.4034
Purity:99%
Melting point:182-183ºC
Appearance:White to creamy white powder
Density:1.21g/cm3
Boiling Point:457.2°C at 760mmHg
Melting Point:182-183ºC
Flash Point:211.2°C
Storage Temperature:Keep in a cool, dry, dark location in a tightly sealed container
Refractive index:-30 °(C=0.4, Pyridine)
Solubility:Ethanol:50 mg/mL, clear, slightly yellow

3.Application:

While Ethynyl Estradiol is readily absorbed when taken orally, Ethynyl Estradiol is also quickly inactivated by the liver.Substitution at C17 of the estrane steroid with an ethinyl group served to provide an estrogen that is much more resistant to degradation and paved the way for the development of oral contraceptives.
Ethynyl Estradiol is absorbed in the small intestine and reaches a serum peak about 2 hours later.It undergoes extensive metabolism in the liver involving the cytochrome P450 3A4 isoenzyme.Ethynyl Estradiol and its metabolites are excreted with the bile.Due to the effect of enterohepatic circulation a second peak is seen several hours later.Individually, wide variations exist in the overall absorption process, and can be further modified by drugs (i.E.Antibiotics) that affect the enterohepatic circulation or liver enzymes.In circulation Ethynyl Estradiol is almost fully bound to plasma albumin.It is metabolized by hydroxylation of the aromatic ring and excreted in both feces and urine, in part as glucuronide and sulfate conjugate.
Ethynyl Estradiol is hormonally effective by activating the estrogen receptor and thus is an estrogen.It finds its most common use in the estrogen-progestin combination preparations of oral contraceptives.Over time, formulations have decreased the Ethynyl Estradiol dose from as high as 100 μG to as low as 10 μG in LoLoestrin Fe.