China (Mainland)
98% Purity Beta-Amyloid (1-42) Human for Pathology of Alzheimer CAS 107761-42 CAS NO.107761-42-2
- Min.Order: 10 Gram
- Payment Terms: T/T,
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Quick Details
- ProName: 98% Purity Beta-Amyloid (1-42) Human f...
- CasNo: 107761-42-2
- Molecular Formula: C203H311N55O60S1
- Appearance: white powder
- Application: Pharmaceutical raw intermediates
- DeliveryTime: Within 5 days after payment
- PackAge: as request
- Port: Wuhan / Shanghai / Guangzhou ...
- ProductionCapacity: 1000 Metric Ton/Month
- Purity: 99%
- Storage: dry, dark and ventilated place
- Transportation: EMS, HKEMS, DHL, TNT, UPS, Fedex...
- LimitNum: 10 Gram
Superiority
Details
Quick Detail:
Product Name: Beta-Amyloid (1-42), Ultra Pure, HFIP
Sequence: Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala- Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-Ile-Ala
Storage: -20°
Molecular Mass: 4514.1 4
Peptide Purity: 98%
Counter Ion: HFIP treated
Supplied As: No salt, as HFIP desalts the sample.
Recombinant. A DNA sequence encoding the human beta-amyloid (1-42)sequence was expressed in E. Coli.
Description:
Beta-amyloid peptide (Abeta), the major constituent of amyloid plaques in the brains of Alzheimer's patients, is thought to be the cause of Alzheimer's Disease (AD)1-3. AD is the most common neurodegenerative disease and afflicts about 10% of the population over 60 4. The abeta, HFIP is described in Stine, et. Al. 3.
1) Yankner, BA, et. Al., (1990) Science, 250: 279-282
2) Selkoe, D. J., (2001) Physiol. Rev, 81: 741-766
3) Stine, W. B. Et. Al., (2003) J. Biol. Chem, 278: 11612-11622
4) Frank, R. A., et. Al., (2003) Neurobiology of Aging, 24: 521-536
HPLC REPORT:
Product Name: Beta-Amyloid(1-42), HFIP
Column: 4.6*250mm, SP-300-5-C4-BIO
Solvent A: 0.1%Trifluoroacetic in 100% Acetonirile
Solvent B: 0.1%Trifluoroacetic in 100% Water
Flow rate: 1.0ml/min
Wavelength: 220nm
RankTimeNameConc. Area
18.000 0.3194914
29.959 1.07116490
310.519 98.231514485
411.018 0.27914298
Total 1001540187
Notes:
This product is a chemically-modified β -amyloid (1-42) precursor, which belongs to GenScript's click peptides. The click peptides; Are best described by the following key features:
1. Enhanced Stability— The O-acyl moiety within the click peptide is stable even under acidic pH.
2. Convenient and quick process— The click peptides can be easily converted to native peptide at pH 7.4 or above.
3. No by-product formation in the conversion process.
4. Superior quality— After the click, the aggregative property of the peptides is significantly minimized compared to its native format