China (Mainland)
Cefetamet Pivoxil Hydrochloride Pharmaceutical Raw Materials CAS NO.111696-23-2
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- Min.Order: 10 Gram
- Payment Terms: L/C
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- Product Details
Keywords
- 111696-23-2
- 111696-23-2
- 111696-23-2
Quick Details
- ProName: Cefetamet Pivoxil Hydrochloride Pharma...
- CasNo: 111696-23-2
- Molecular Formula: C20H25N5O7S2.HCl
- Appearance: white crystalline powder
- Application: use in chemical
- DeliveryTime: within a week
- PackAge: bags
- Port: Shanghai
- ProductionCapacity: 12 Kilogram/Day
- Purity: 99%
- Storage: Kept in a well-closed, light-resistant...
- Transportation: by sea or express
- LimitNum: 10 Gram
- Moisture Content: 0.001
- Impurity: 0.001
- Water content: 0%
Superiority
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Details
Cefetamet Pivoxil Hydrochloride Pharmaceutical Raw Materials
1. Basic Info
Name: 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid,7-[[(2Z)-2-(2-amino-4-thiazolyl)-2-(methoxyimino)acetyl]amino]-3-methyl-8-oxo-,(2,2-dimethyl-1-oxopropoxy)methyl ester, hydrochloride (1:1), (6R,7R)-
Synonyms: 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid, 7-[[(2-amino-4-thiazolyl)(methoxyimino)acetyl]amino]-3-methyl-8-oxo-,(2,2-dimethyl-1-oxopropoxy)methyl ester, monohydrochloride, [6R-[6a,7b(Z)]]-;5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid,7-[[(2Z)-(2-amino-4-thiazolyl)(methoxyimino)acetyl]amino]-3-methyl-8-oxo-,(2,2-dimethyl-1-oxopropoxy)methyl ester, monohydrochloride, (6R,7R)- (9CI);Cefetamet (pivaloyloxy)methyl ester hydrochloride;Cefyl;Ro 15-8075;
CAS Registry number: 111696-23-2
Molecular Formula: C20H25N5O7S2.HCl
Boiling Point: 732.3 °C at 760 mmHg
Flash Point: 396.7 °C
Density: g/cm3
The hydrochloride salt form of cefetamet pivoxil, a pivalate ester prodrug form of a cefetamet. Afteroral administration of cefetamet pivoxil hydrochloride, the ester bond is cleaved, releasing activecefetamet.
2. Description
Two simple, rapid, specific and accurate analytical methods for the estimation of cefetamet pivoxil hydrochloride and pitavastatin calcium in bulk drug and in their tablet formulations are described. These methods are based on difference spectrophotometry, wherein the measurement is done at maximum 221 nm and minimum 275 nm for cefetamet whereas at maximum 240 nm and minimum 259 nm for pitavastatin.
The Beer's law was obeyed in the concentration range of 1-35 μg/ml and 1-25 μg/ml and the molar absorptivities were 1.3×104 lit mol−1 cm−1 and 2.4×104 lit mol−1 cm−1 for cefetamet pivoxil hydrochloride and pitavastatin calcium, respectively. The proposed methods were validated and successfully applied to the estimation of drugs in tablet formulations.
The invention discloses a cefetamet pivoxil hydrochloride compound and a preparation method thereof. In the method, the crude product of cefetamet pivoxil hydrochloride prepared by the prior art is processed by the following steps to obtain a relatively pure cefetamet pivoxil hydrochloride compound: the crude product of cefetamet pivoxil hydrochloride is dissolved in methanol or alcohol, and then sodium hydroxide solution or potassium hydroxide solution is added the mixed solution is stirred for reaction and hydrolyzed to obtain cefetamet pivoxil sodium salt or cefetamet pivoxil sylvite which is then absorbed with added active carbon and filtered and then iodo-ester is added and reaction is conducted in the presence of an organic solvent to obtain cefetamet pivoxil the cefetamet pivoxil dissolves in isopropyl alcohol, hydrochloric acid is added in a dropwise manner and cyclohexane is added, and the mixed solution is stirred to separate out crystal and the crystal is filtered, washed and dried to obtain cefetamet pivoxil hydrochloride.