Aminoglycoside Antibiotics Neomycin Sulfate CAS 1405-10-3 CAS NO.1405-10-3

Aminoglycoside Antibiotics Neomycin Sulfate CAS 1405-10-3

Neomycin Sulphate Basic Info: 
Name: Neomycin Sulphate
Neomycin Sulphate CAS No.: 1405-10-3
Neomycin Sulphate Formula: C23H48N6O17S
Neomycin Sulphate Molecular Weight: 712.7222
Neomycin Sulphate EINECS: 215-773-1
Neomycin Sulphate Boiling Point: 1046.1° C at 760 mmHg
Neomycin Sulphate Flash Point: 586.5° C
Neomycin Sulphate Purity: 99%
Neomycin Sulphate Appearance: White or yellowish-white powder
Neomycin Sulphate Usage: As a broad-spectrum antibiotic, against Staphylococcus aureus, diphtheria and anthrax role


What is Neomycin Sulphate

Neomycin is an aminoglycoside antibiotic found in many topical medications such as creams, ointments, and eyedrops. The discovery of neomycin dates back to 1949. It was discovered in the lab of Selman Waksman. Neomycin belongs to aminoglycoside class of antibiotics that contain two or more aminosugars connected by glycosidic bonds.
Neomycin Sulfate Usages and functions: 

To reduce the development of drug-resistant bacteria and maintain the effectiveness of Neomycin Sulfate tablets and other antibacterial drugs, Neomycin Sulfate tablets should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria. When culture and susceptibility information are available, they should be considered in selecting or modifying antibacterial therapy. In the absence of such data, local epidemiology and susceptibility patterns may contribute to the empiric selection of therapy.

1) Suppression of Intestinal Bacteria
Neomycin Sulfate tablets are indicated as adjunctive therapy as part of a regimen for the suppression of the normal bacterial flora of the bowel, e.g., preoperative preparation of the bowel. It is given concomitantly with erythromycin enteric-coated base 

2) Hepatic Coma (Portal-Systemic Encephalopathy)
Neomycin Sulfate has been shown to be effective adjunctive therapy in hepatic coma by reduction of the ammonia-forming bacteria in the intestinal tract. The subsequent reduction in blood ammonia has resulted in neurologic improvement.


Contraindications while use Neomycin Sulfate: 
Neomycin Sulfate oral preparations are contraindicated in the presence of intestinal obstruction and in individuals with a history of hypersensitivity to the drug.

Patients with a history of hypersensitivity or serious toxic reaction to other aminoglycosides may have a cross-sensitivity to neomycin. Neomycin Sulfate oral preparations are contraindicated in patients with inflammatory or ulcerative gastrointestinal disease because of the potential for enhanced gastrointestinal absorption of neomycin.