China (Mainland)
Isosorbide mononitrate prevent attacks of angina pectoris CAS NO.16051-77-7
- Min.Order: 10 Gram
- Payment Terms: L/C,T/T,Other
- Product Details
Keywords
- Isosorbide mononitrate
- purity 98% Isosorbide mononitrate
- high quality cas 16051-77-7
Quick Details
- ProName: Isosorbide mononitrate prevent attacks...
- CasNo: 16051-77-7
- Molecular Formula: C6H9NO6
- Appearance: A white crystalline power
- Application: Stored at room temperature - 15 -30°C ...
- DeliveryTime: within in 5-7 working days after recei...
- PackAge: 25kg/barrel or as customers' requireme...
- Port: Wuhan, Shanghai, Guangzhou, Tianjin po...
- ProductionCapacity: 200 Kilogram/Month
- Purity: ≥96%
- Storage: Store in a cool, dry area
- Transportation: by sea/by express
- LimitNum: 10 Gram
Superiority
Details
[Chemical name] C6H9NO6
[Molecular Structure]
[CAS NO.] 16051-77-7
[Indication] Isosorbide mononitrate is given to prevent attacks of angina pectoris but is not recommended in the treatment of an angina attack.
[Action] Isosorbide mononitrate causes the blood vessels in the body to dilate. This has several effects on the heart including improving the supply of oxygen to the heart and reducing the amount of work the heart has to do. These effects reduce the risk of an angina attack occurring.
[Assay] ≥96.0%
[Package] 25kg /barrel
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Pharmacology |
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Indication |
For the prevention of angina pectoris due to coronary artery disease and the treatment of acute and chronic angina pectoris, hypertension, and myocardial infarction. |
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Pharmacodynamics |
Isosorbide-5-mononitrate, the long-acting metabolite of isosorbide dinitrate, is used as a vasodilatory agent in the management of angina pectoris. By dilating the vessels, it lowers the blood pressure and reduces the left ventricular preload and afterload, therefore, leads to a reduction of myocardial oxygen requirement. |
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Mechanism of action |
Similar to other nitrites and organic nitrates, Isosorbide Mononitrate is converted to nitric oxide (NO), an active intermediate compound which activates the enzyme guanylate cyclase (Atrial natriuretic peptide receptor A). This stimulates the synthesis of cyclic guanosine 3',5'-monophosphate (cGMP) which then activates a series of protein kinase-dependent phosphorylations in the smooth muscle cells, eventually resulting in the dephosphorylation of the myosin light chain of the smooth muscle fiber. The subsequent release of calcium ions results in the relaxation of the smooth muscle cells and vasodilation. |
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