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Home > Products >  Sulfadoxine for respiratory/urinary tract

Sulfadoxine for respiratory/urinary tract CAS NO.2447-57-6

  • Min.Order: 10 Gram
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Keywords

  • Sulfadoxine
  • purity 99% Sulfadoxine
  • high quality cas 2447-57-6

Quick Details

  • ProName: Sulfadoxine for respiratory/urinary tr...
  • CasNo: 2447-57-6
  • Molecular Formula: C12H14N4O4S
  • Appearance: A white to off-white, crystalline powd...
  • Application: Ultra long-acting sulfonamide for the ...
  • DeliveryTime: within in 5-7 working days after recei...
  • PackAge: 25kg/barrel or as customers' requireme...
  • Port: Wuhan, Shanghai, Guangzhou, Tianjin po...
  • ProductionCapacity: 200 Kilogram/Month
  • Purity: ≥99%
  • Storage: Store in dry, dark and ventilated plac...
  • Transportation: by sea/by express
  • LimitNum: 10 Gram

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Details

Name

Sulfadoxine

Type

Small Molecule

Groups

Approved

Description

A long acting sulfonamide that is used, usually in combination with other drugs, for respiratory, urinary tract, and malarial infections. [PubChem]

Structure

Thumb

 

Pharmacology

Indication

Sulfadoxine is used in combination with pyrimethamine for the treatment or prevention of malaria. It can also be used to treat various infections in livestock as well. Sulfadoxine and pyrimethamine is indicated for the treatment of Plasmodium falciparum malaria in those patients in whom chloroquine resistance is suspected.

Pharmacodynamics

Sulfadoxine helps inhibit the enzyme dihydropteroate synthetase which is an enzyme necessary in the conversion of PABA to folic acid. As folic acid is vital to the synthesis, repair, and methylation of DNA which is vital to cell growth in Plasmodium falciparum. With this vital nutrient lacking, the parasite has difficulty in reproducing.

Mechanism of action

Sulfadoxine is a sulfa drug, often used in combination with pyrimethamine to treat malaria. This medicine may also be used to prevent malaria in people who are living in, or will be traveling to, an area where there is a chance of getting malaria. Sulfadoxine targets Plasmodium dihydropteroate synthase and dihydrofolate reductase. Sulfa drugs or Sulfonamides are antimetabolites. They compete with para-aminobenzoic acid (PABA) for incorporation into folic acid. The action of sulfonamides exploits the difference between mammal cells and other kinds of cells in their folic acid metabolism. All cells require folic acid for growth. Folic acid (as a vitamin) diffuses or is transported into human cells. However, folic acid cannot cross bacterial (and certain protozoan) cell walls by diffusion or active transport. For this reason bacteria must synthesize folic acid from p-aminobenzoic acid.

 

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