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Home > Products >  High purity Pyrimethamine for antifungal drugs with good quality

High purity Pyrimethamine for antifungal drugs with good quality CAS NO.58-14-0

  • Min.Order: 10 Gram
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  • Product Details

Keywords

  • Pyrimethamine
  • purity 99% Pyrimethamine
  • high quality cas 58-14-0

Quick Details

  • ProName: High purity Pyrimethamine for antifung...
  • CasNo: 58-14-0
  • Molecular Formula: C12H13ClN4
  • Appearance: white solid
  • Application: Antifungal Drugs
  • DeliveryTime: within in 5-7 working days after recei...
  • PackAge: 25kg/paper drum or as customers' requi...
  • Port: Wuhan, Shanghai, Guangzhou, Tianjin po...
  • ProductionCapacity: 250 Kilogram/Month
  • Purity: ≥99%
  • Storage: Keep container tightly closed in a coo...
  • Transportation: by sea/by express
  • LimitNum: 10 Gram
  • Grade: Pharma Grade
  • Standard: BP2000.98/USP25.27

Superiority

1, High quality with competitive price:

  We are manufacturer and can provide high quality products with factory price.

2, Fast and safe delivery

  1) Parcels can be sent out within 24 hours after payment. Tracking number is available.

  2) Secure and discreet shipment. You have various choices of transportation methods.

3, We have clients throughout the world.

  1) Professional service and rich experience make customers feel at ease, adequate stock and fast delivery meet your desire.

  2) Market feedback and goods feedback are appreciated, meeting customers's requirement is our responsibility.

  3) High quality, competitive price, fast delivery, first-class service gain the trust and praise from the customers.

Details

Basic information

Product Name:

Pyrimethamine

Synonyms:

2,4-Diamino-5-(4-chlorophenyl)-6-ethylpyrimidine;2,4-Diamino-5-chlorophenyl-6-ethylpyrimidine;2,4-Pyrimidinediamine, 5-(4-chlorophenyl)-6-ethyl-;2,4-Pyrimidinediamine, 5-(p-chlorophenyl)-6-ethyl-;2,4-Pyrimidinediamine,5-(4-chlorophenyl)-6-ethyl-;4753 R.P.;4753r.p.;5-(4’-chlorophenyl)-2,4-diamino-6-ethylpyrimidine

CAS:

58-14-0

MF:

C12H13ClN4

MW:

248.71

Product Categories:

APIs & Intermediate;Pyrimidine;Organics;Amines;Bases & Related Reagents;Heterocycles;Intermediates & Fine Chemicals;Nucleotides;Pharmaceuticals;Inhibitor;Heterocycle-Pyrimidine series;DARAPRIM

Mol File:

58-14-0.mol

Pyrimethamine Structure

 

Chemical Properties

melting point 

233-234°C

boiling point 

491.5 °C at 760 mmHg

density 

1.305 g/cm3

flashing point 

251 °C

vapor pressure 

8.34E-10 mmHg at 25°C

storage temp. 

0-6°C

Water Solubility 

<0.01 g/100 mL at 21 ºC

Stability

Stable, but light sensitive. Combustible. Incompatible with strong oxidizing agents.

 

Usage And Synthesis

Chemical Properties

White Solid

Usage

Dihydrofolate reductase inhibitor; generally used in combination with other antimicrobial agents. Antiprotozoal (Toxoplasma); antimalarial

For the treatment of toxoplasmosis and acute malaria; For the prevention of malaria in areas non-resistant to pyrimethamine

Air & Water Reactions

Insoluble in water.

Reactivity Profile

Pyrimethamine is sensitive to exposure to light . Neutralizes acids to form salts plus water in exothermic reactions. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen may be generated in combination with strong reducing agents, such as hydrides.

Fire Hazard

Flash point data for Pyrimethamine are not available; however, Pyrimethamine is probably combustible.

Biological Activity

Potent inhibitor of multi-drug and toxin extrusion (MATE) transporters (K i values are 46 and 77 nM for human MATE2-K-HEK293 and MATE1-HEK293 cells respectively). Also inhibits dihydrofolate reductase (DHFR).

 

About us:

Hubei Jusheng Technology Co., Ltd., is a large group corporation which engaged in the R&D and manufacture of chemicals, Pharmaceuticals and intermediates. We have earned ourselves a good reputation at home and abroad with advanced technology, standardized management and well established service systerm. We have developed to a very famous group corporation Enterprise in chemical industry step by step. 

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