China (Mainland)
High purity Leflunomide with best price and good quality CAS NO.75706-12-6
- Min.Order: 10 Gram
- Payment Terms: L/C,T/T,Other
- Product Details
Keywords
- Leflunomide
- purity 99% Leflunomide
- high quality cas 75706-12-6
Quick Details
- ProName: High purity Leflunomide with best pric...
- CasNo: 75706-12-6
- Molecular Formula: C12H9F3N2O2
- Appearance: off-white crystalline powder
- Application: API
- DeliveryTime: within in 5-7 working days after recei...
- PackAge: 25kg/paper drum or as customers' requi...
- Port: Wuhan, Shanghai, Guangzhou, Tianjin po...
- ProductionCapacity: 250 Kilogram/Month
- Purity: 98.0% - 102.0%
- Storage: Keep container tightly closed in a coo...
- Transportation: by sea/by express
- LimitNum: 10 Gram
- Grade: Pharma Grade
Superiority
1, High quality with competitive price:
We are manufacturer and can provide high quality products with factory price.
2, Fast and safe delivery
1) Parcels can be sent out within 24 hours after payment. Tracking number is available.
2) Secure and discreet shipment. You have various choices of transportation methods.
3, We have clients throughout the world.
1) Professional service and rich experience make customers feel at ease, adequate stock and fast delivery meet your desire.
2) Market feedback and goods feedback are appreciated, meeting customers's requirement is our responsibility.
3) High quality, competitive price, fast delivery, first-class service gain the trust and praise from the customers.
Details
Basic information
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Product Name: |
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Synonyms: |
LEFLUNOMIDE;HWA 486;ALPHA,ALPHA,ALPHA-TRIFLUORO-5-METHYL-4-ISOXAZOLECARBOXY-P-TOLUIDIDE;5-METHYLISOXAZOLE-4-(4-TRIFLUOROMETHYLCARBOXANILIDE);5-METHYL-N-[4-(TRIFLUOROMETHYL)PHENYL]-4-ISOXAZOLECARBOXAMIDE;N-(4-TRIFLUOROMETHYLPHENYL)-5-METHYLISOXAZOL-4-CARBOXAMIDE;5-methylisoxazole-4-carboxylicacid(4-trifluoromethyl)anilide;5-methyl-n-(4-(trifluoromethyl)phenyl)-4-isoxazolecarboxamid |
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CAS: |
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MF: |
C12H9F3N2O2 |
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MW: |
270.21 |
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Product Categories: |
Active Pharmaceutical Ingredients;API;Osteoarthritis and Rheumatoid Arthritis;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;Cytokine signaling;Aromatics;Heterocycles;An immunosuppressive agent;CARDENE;Other APIs |
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Mol File: |
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Chemical Properties |
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melting point |
163-168°C |
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boiling point |
289.3 °C at 760 mmHg |
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density |
1.392 g/cm3 |
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flashing point |
128.8 °C |
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vapor pressure |
0.0020000000949949 mmHg at 25°C |
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storage temp. |
2-8°C |
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Quality Index |
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Relative Substances： |
A ≤0.01% total impurite ≤0.4% |
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Loss on Drying： |
≤3.0% |
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Heavy Metal： |
≤10ppm |
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Residue on Ignition： |
≤0.1% |
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Content： |
98.0%~102.0% |
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conclusion |
(USP31) （BP2008） |
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Usage And Synthesis |
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Chemical Properties |
Off White Crystalline Solid |
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Usage |
An immunosuppressive. Inhibits T and B cell proliferation. Activity is attributed mainly to its metabolite, a malononitrile derivative, which is beleived to inhibit dihydroorotate dehydrogenase as well as several protein tyrosine kinases. Therapeutical |
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vasodilator |
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anti-Altzheimer therapeutic |
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Biological Activity |
Immunosuppressant agent. In vitro the active metabolite A77 1726 (RS-61980) inhibits dihydroorotate dehydrogenase (K i = 2.7 μ M) and de novo pyrimidine synthesis in T-cells; blocks lymphocyte cell cycle progression and proliferation. A77 1726 also inhibits anti-CD3/CD28-induced cytokine production in PBMC cells (IC 50 = 21-27 μ g/ml). In vivo reduces inflammation in several animal models of autoimmune disease, arthritis, asthma and graft rejection. |
About us:
Hubei Jusheng Technology Co., Ltd., is a large group corporation which engaged in the R&D and manufacture of chemicals, Pharmaceuticals and intermediates. We have earned ourselves a good reputation at home and abroad with advanced technology, standardized management and well established service systerm. We have developed to a very famous group corporation Enterprise in chemical industry step by step.
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