- Product Details
Keywords
- Milrinone
- purity 99% Milrinone
- high quality cas 78415-72-2
Quick Details
- ProName: High quality Milrinone with best price
- CasNo: 78415-72-2
- Molecular Formula: C12H9N3O
- Appearance: Almost white crystalline powder
- Application: congestive heart failure unresponsive ...
- DeliveryTime: within in 5-7 working days after recei...
- PackAge: 5kg/barrel or as customers' requiremen...
- Port: Wuhan, Shanghai, Guangzhou, Tianjin po...
- ProductionCapacity: 200 Kilogram/Month
- Purity: ≥99.8%
- Storage: Stored as directed away from heat and ...
- Transportation: by sea/by express
- LimitNum: 10 Gram
Superiority
Details
Name |
Milrinone |
---|---|
Type |
Small Molecule |
melting point |
>300 °C |
water solubility |
Slightly soluble |
Groups |
Approved |
Description |
A positive inotropic cardiotonic agent with vasodilator properties. It inhibits cAMP phosphodiesterase activity in myocardium and vascular smooth muscle. Milrinone is a derivative of amrinone and has 20-30 times the ionotropic potency of amrinone. [PubChem] |
Structure |
Pharmacology |
|
---|---|
Indication |
Indicated for the treatment of congestive heart failure. |
Pharmacodynamics |
Milrinone, a synthetic dimethylxanthine derivative structurally related to theophylline and caffeine, is used in the treatment of peripheral vascular diseases and in the management of cerebrovascular insufficiency, sickle cell disease, and diabetic neuropathy. |
Mechanism of action |
Milrinone inhibits erythrocyte phosphodiesterase, resulting in an increase in erythrocyte cAMP activity. Subsequently, the erythrocyte membrane becomes more resistant to deformity. Along with erythrocyte activity, Milrinone also decreases blood viscosity by reducing plasma fibrinogen concentrations and increasing fibrinolytic activity. |
Absorption |
Milrinone is rapidly and almost completely absorbed after oral administration. Bioavailability is 92% (in healthy volunteers). |
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