China (Mainland)
Bulk offering first-class Ibrutinib 936563-96-1 supplier CAS NO.936563-96-1
- FOB Price: USD: 1.00-2.00 /Metric Ton Get Latest Price
- Min.Order: 10 Gram
- Payment Terms: L/C
- Available Specifications:
EP/BP/USP(1-10)Metric TonEP/BP/USP(11-100)Metric Ton
- Product Details
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- bulk offering Ibrutinib
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Quick Details
- ProName: Bulk offering first-class Ibrutinib 93...
- CasNo: 936563-96-1
- Molecular Formula: C25H24N6O2
- Appearance: white crystalline powder
- Application: use in chemical
- DeliveryTime: within a week
- PackAge: bags
- Port: Shanghai
- ProductionCapacity: 12 Kilogram/Day
- Purity: 99%
- Storage: Kept in a well-closed, light-resistant...
- Transportation: by sea or express
- LimitNum: 10 Gram
- Moisture Content: 0.001
- Impurity: 0.001
- Water content: 0%
Superiority
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1,Best Quality: Our products have exported to Germany, Spain, UK, USA, Australia, Middle East, and so on other countries, and we have got very good feedback from our customers.so you can trust us. 2, Payment method: for example T/T, Westerm Union,other 3, Excellent Service: Best service and after-sales service to all clients. 1)We will ship the goods within 5days after get your payments.If you want to cancel or change order, please tell me within 24hours after you finish the payment.. 2)We will ship the goods that you order from us by DHL, UPS, TNT and EUB.We will decided to choose which courier depend on different countries.To find the best way to delivery the goods for you. 3)As usual you can get the goods with in 4-7days.If the goods were lost or not received for other reasons, please contact us immediately. 4,Fast and safe delivery: Sample Order : As usual you can get the goods within 4-7days. We can send it via HKems, HK Air Post, DHL or other methods. We have a professional and stable logistics, and we can deliver the package smoothly around 3 to 5 days. Bulk Order: Shipped via sea or air, it's according to your requirement, delivery time is 7-15days after payment. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our customers and principals. With our high-performance teamwork centers and associated production sites for custom synthesis, we ensure effective professional response and offer extensive applications-related consulting and compliance regulation services. |
Details
Bulk offering first-class Ibrutinib 936563-96-1 supplier
Raw Pharmaceutical 99.9% Purity Ibrutinib For Treat B Cell Cancers CAS 936563-96-1
Ibrutinib (Imbruvica) is a small molecule drug that binds permanently to a protein, Bruton's tyrosine kinase (BTK), that is important in B cells; the drug is used to treat B cell cancers like mantle cell lymphoma, chronic lymphocytic leukemia, and Waldenström's macroglobulinemia, a form of non-Hodgkin's lymphoma.
Quick View:
| Product Name | Ibrutinib |
| CAS | 936563-96-1 |
| Appearance | White Crystalline Powder |
| MF | C25H24N6O2 |
| MW | 440.5 |
| Purity | 99%min |
| Application |
1.Mantle cell lymphoma (MCL) who have received at least one prior therapy. 2.Chronic lymphocytic leukemia (CLL) who have received at least one prior therapy. 3.Waldenstrom's macroglobulinemia. |
Descriptions:
Ibrutinib is a highly selective Bruton’s tyrosine kinase (Btk) irreversible inhibitor.PCI-32765 (Ibrutinib) is a selective and irreversible pyrrolopyrimidine-based inhibitor of BTK with IC50 of 0.5 nM. [1] PCI-32765 binds irreversibly to Cys-481 in BTK and thus is only active with other kinases with such a modifiable cysteine residue. In DOHH2 cells, in which the BCR pathway can be activated by anti-IgG, PCI-32765 inhibits autophosphorylation of BTK (IC50, 11 nM), BTK's physiological substrate, PLCg (IC50, 29 nm), and downstream ERK (IC50, 13 nm).
Ibrutinib is used to treat chronic lymphocytic leukemia, Waldenstrom's macroglobulinemia, and as a second-line treatment for mantle cell lymphoma, marginal zone lymphoma, and chronic graft vs host disease.
COA:
| Items | Specifications | Results |
| Appearance | White to whitish crystal powder | Conforms |
| Loss on drying | NMT 0.5% | 0.33% |
| Residue on ignition | NMT 0.1% | Conforms |
| Heavy metal | NMT 20ppm | Conforms |
| Assay (HPLC) | NLT 99.5% | 99.77% |
| Related substances | NMT 0.5% | 0.23% |
| Single impurity | NMT 0.1% | 0.07% |
| Conclusion | Complies to the Enterprise standard. | |